Immunoglobulin a qn serum high cancer

Request an Appointment. 410-955-5000 Maryland. 855-695-4872 Outside of Maryland. +1-410-502-7683 International. Find a Doctor. An IgG deficiency is a health problem in which your body doesn’t make enough Immunoglobulin G (IgG). People with IgG deficiency are more likely to get infections.

Serum immunoglobulins are part of the adaptive immune system and comprise five classes, including immunoglobulin A, G, and M (IgA, IgG, and IgM). IgM provides a rapid immune response and is involved in tissue homeostasis, whereas IgG and IgA are long-lasting high-affinity antibodies, the latter mainly providing mucosal immunity ( 1 ).Your body makes several types of immunoglobulins or antibodies. They are called IgM, IgG, IgA, and IgE. IgG is found in your blood and tissue. IgM is mostly found in your blood. IgA is found at high levels in fluid your mucus membranes make, such as saliva, tears, and nasal secretions. IgE is mostly attached to immune system cells in your blood ...Plasma cells are protein-making cells participating in humoral immune responses against bacteria, viruses, fungi, parasites, cellular antigens, chemicals, and synthetic substances. [1] Immunoglobulins constitute about 20% of the protein in plasma. The immunogen or antigen reacts with a B-cell receptor (BCR) on the cell surface of B …The gamma globulin band as seen in conventional serum protein electrophoresis consists of 5 immunoglobulins. In normal serum, about 5% is IgM. Elevations of IgM may be due to polyclonal immunoglobulin production. Monoclonal elevations of IgM occur in macroglobulinemia.2. Your bloodwork shows specific elevated antibodies. The next step to diagnosing celiac disease is a basic and accurate blood screening to look at your Immunoglobulin A or IgA level. Dr. Dale explains, “Immunoglobulins are antibodies that your body produces, and there are a variety of different classes of immunoglobulins.However, some people who have IgA deficiency experience pneumonia, ear infections, sinus infections, allergies, asthma and diarrhea. Autoimmune diseases, in which your immune system attacks particular organs or tissues in your own body, can be found with selective IgA deficiency. Common autoimmune conditions found with IgA deficiency …

Additional Information. Two classes of IgA have been identified in humans: IgA 1, which accounts for 80% to 90% of total serum IgA, and IgA 2 which is the major subclass in secretions such as milk. The two subclasses appear to be regulated independently. Antigenic sites on the IgA subclasses are responsible for the anaphylactic transfusion ...Introduction. Because of decreased levels of IgG in the blood and normal or elevated levels of IgM, most individuals with hyper IgM syndrome (HIGM) are susceptible to recurrent and severe infections, including opportunistic infections, which are infections by organisms that do not normally infect healthy individuals, and are susceptible to an increased risk of …Objectives The major objective of the Alliance is to discover and develop molecular markers for early detection of cancer by conducting innovative, The major objective of the Allia...Immunoglobulin A, Qn, Serum 483 High mg/dL 90 - 386 Testosterone, Serum Testosterone, Serum 345 Low ng/dL 348 ... Sorry I'm just freaking out reading the internet about cancer and all kinds of bad things. DrRussMD, Expert. At that level, nothing. That is well within lab variability. As I said, in the absence of other abnormal tests, it is ...According to the American Cancer Society, kidney cancer is among the 10 most common cancers in the U.S. The observed five-year survival rate of people who are diagnosed with kidney... Additional Information. Increased monoclonal IgA may be produced in lymphoproliferative disorders, especially multiple myeloma and “Mediterranean” lymphoma involving bowel. An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces, where IgA is largely produced. Takeaway. Immunoglobulins, or antibodies, are produced by white blood cells. They help your body defend against infections and conditions like cancer. Tests …

Immunoglobulin A (IgA), one of the five primary immunoglobulins, plays a pivotal role in mucosal homeostasis in the gastrointestinal, respiratory, and genitourinary tracts, functioning as the dominant antibody of immunity in this role.[1] It is the second most abundant immunoglobulin type found in the body and, consequently, has a crucial role in protection against antigens.[2] IgA production ...Abstract. Serum immunoglobulin levels IgA, IgG, and IgM have been estimated in 92 patients with breast cancer and 50 control patients, 40 of whom had benign disease of the breast. In patients with breast cancer, IgA was significantly raised at all stages and IgG was significantly reduced, but the two abnormalities were not necessarily concomitant.Introduction. Chronic diseases, such as cardiovascular diseases (CVD), cancer, and age-related diseases have long been considered among the most important global public health issues .CVD are a group of disorders that affect the heart and blood vessels, and remain a major cause of mortality and morbidity worldwide .Metabolic …Interpret your laboratory results now. Free light chains will normally be present in the blood at low levels, with a kappa/lambda ratio of approximately 0.26 to 1.65 for individuals with normal kidney function. Excess production of free kappa or lambda chains can alter this ratio. Monoclonal free light chains are found in serum of patients with ...

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Abnormal serum immunoglobulin (Ig) free light chains (FLC) are established biomarkers of early disease in multiple B-cell lymphoid malignancies, including chronic lymphocytic leukemia (CLL). Heavy ...Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency characterized by a decreased amount of serum IgA and a concomitant lack of secretory IgA. Other immunoglobulin levels are normal. By the International Consensus definition, the diagnosis is established in individuals older than four years whose blood levels of IgA are below 7 mg/dl but have normal levels of IgG and ...Project Title/Research Areas: Early Detection of Ovarian Cancer by Serum Marker and Targeted Ultrasound ImagingPrincipal Investigator/Institution: Animesh Project Title/Research Ar...Serum immunoglobulins are part of the adaptive immune system and comprise five classes, including immunoglobulin A, G, and M (IgA, IgG, and IgM). IgM provides a rapid immune response and is involved in tissue homeostasis, whereas IgG and IgA are long-lasting high-affinity antibodies, the latter mainly providing mucosal immunity ( 1 ).Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency characterized by a decreased amount of serum IgA and a concomitant lack of secretory IgA. Other immunoglobulin levels are normal. By the International Consensus definition, the diagnosis is established in individuals older than four years whose blood levels of IgA are below 7 mg/dl but have normal levels of IgG and ...Immunoglobulin G, Qn, Serum. Optimal Result: 586 - 1602 mg/dL. Interpret your laboratory results now. Immunoglobulin G (IgG), quantified in serum and expressed in quantitative terms, is a fundamental marker in immunology and a predominant antibody class in the body's immune response. Representing about 75% of serum antibodies in …

Polyclonal gammopathy, also called hypergammaglobulinemia, happens when your immune system makes too many immunoglobulins (antibodies). These extra antibodies show that your immune system is working too hard. Your healthcare provider treats the condition that’s causing your immune system to produce too many antibodies. Medically Reviewed.In a single day in parliament, the Modi government had three estimates for vaccine production Serum Institute of India and Bharat Biotech. The Narendra Modi government seems unsure...IgA vasculitis, formerly called Henoch-Schönlein purpura or HSP, is a disease that causes the antibody immunoglobulin A to collect in small blood vessels, which then become inflamed and leak blood. Nearly all people with IgA vasculitis develop a red or purple rash.An immunoglobulins test is done to measure the level of immunoglobulins, also known as antibodies, in your blood. Antibodies are substances made by the body's immune system in response to bacteria, viruses, fungus, animal dander, or cancer cells. Antibodies attach to the foreign substances so the immune system can destroy them.Nov 9, 2021 · Immunoglobulin M (IgM) – IgM antibodies are produced as a body’s first response to a new infection or to a new “non-self” antigen, providing short-term protection. They increase for several weeks and then decline as IgG production begins. Immunoglobulin G (IgG) – About 70-80% of the immunoglobulins in the blood are IgG. The gamma globulin band as seen in conventional serum protein electrophoresis consists of 5 immunoglobulins. In normal serum, about 80% is IgG. Elevations of IgG may be due to polyclonal immunoglobulin production. Monoclonal elevations of IgG characterize multiple myeloma. Monoclonal gammopathies of all types may lead to a spike in the gamma ...Ovarian cancer, Lymphoma [3], Multiple myeloma, Fibrosarcoma, Extramedullary myeloid tumor, small cell lung cancer: ... we observed that a steady subset of our initial presentations were characterized by nonspecific clinical findings and elevated serum acute phase reactants. This type of initial presentation was considered worthy of …Immunoglobulin A (IgA), Serum. Useful For. Detection or monitoring of IgA monoclonal gammopathies and IgA-related immune deficiencies. Testing Algorithm. The following algorithms are available: - Celiac Disease Comprehensive Cascade Test Algorithm. - Celiac Disease Diagnostic Testing Algorithm. - Celiac Disease Gluten-Free Cascade Test Algorithm.

Additional Information. Increased monoclonal IgA may be produced in lymphoproliferative disorders, especially multiple myeloma and “Mediterranean” lymphoma involving bowel. An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces, where IgA is largely produced.

Dec 15, 2007 · Serum IgA tTG levels typically decrease as patients maintain a glutenfree diet. Celiac disease (or celiac sprue) is an autoimmune disorder with a prevalence of approximately 0.5 to 1 percent in ... Immunoglobulin A (IgA) is an antibody that’s part of your immune system. IgA is found in mucous membranes, especially in the respiratory and digestive tracts. It is also found in saliva, tears, and breastmilk. IgA deficiency is a genetic health problem that can be passed down through families. Most people with an IgA deficiency don’t have ...IgA nephropathy (nuh-FROP-uh-thee), also known as Berger disease, is a kidney disease. It happens when a germ-fighting protein called immunoglobulin A (IgA) builds up in the kidneys. This causes a type of swelling called inflammation that, over time, can make it harder for the kidneys to filter waste from the blood.It also provides a measure of the concentration of the major immunoglobulin types in the blood, including IgG, IgA, and IgM. The serum free light chain assay provides the concentration of the two light chains that are found in the body — the kappa and lambda light chains — and the ratio between these light chains.Immunoglobulin A (IgA), one of the five primary immunoglobulins, plays a pivotal role in mucosal homeostasis in the gastrointestinal, respiratory, and genitourinary tracts, functioning as the dominant antibody of immunity in this role.. Total IgA (Immunoglobulin A), expressed in milligrams per deciliter (mg/dL), is a crucial marker in clinical … Serum IgA and IgG (but not IgM) tended to increase in parallel with these categories of serum IL-6 levels (P for trend = 0·01, 0·03 and 0·59, respectively) (Fig. 5). No clear-cut associations were observed between IL-6 levels and sex, alcohol consumption, smoking or any of the common metabolic abnormalities studied (data not shown). In AIP patients, elevated serum IgG4 (>1.4 g/L) is observed in 70–80% of the cases, as well as in 10% of pancreatic cancer patients. However, as 5% of the normal population also has elevated IgG4 levels, this makes it only suitable for diagnosis in combination with other features of AIP. Structure

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Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency characterized by a decreased amount of serum IgA and a concomitant lack of secretory IgA. Other immunoglobulin levels are normal. By the International Consensus definition, the diagnosis is established in individuals older than four years whose blood levels of IgA are below 7 mg/dl but have normal levels of IgG and ...Selective immunoglobulin M (SIgM) deficiency is a rare form of dysgammaglobulinemia characterized by an isolated low level of serum immunoglobulin M (IgM). [] Reported IgM concentrations in SIgM deficiency vary from 40 mg/dL (though some sources say 20 mg/dL) to undetectable levels (reference range 45-150 mg/dL in adults). [] Recent series report …Immunoglobulin A (IgA) is an antibody blood protein that’s part of your immune system. Your body makes IgA and other type of antibodies to help fight off sickness. Having an …14 Citations. 6 Altmetric. Metrics. Abstract. Numerous studies have reported expressions of immunoglobulins (Igs) in many human tumor tissues and cells. Tumor …An IgA test measures the blood level of immunoglobulin A, one of the most common types of antibodies in the body. Antibodies (also called immunoglobulins) are proteins the immune system makes to recognize and get rid of germs. Normally, high IgA levels are found in the body's mucous membranes, especially the respiratory passages and ...Multivariate Cox regression (adjusted for age, gender, education, CCI, and serum glucose level) for the association between immunoglobulin G and the risk of pancreatic cancer showed that, compared to the IgG reference level of 6.10–14.99 g/L, there was a positive association for those with IgG levels <6.10 g/L [HR: 1.69 (95% CI …Conclusions: Serum immunoglobulin levels in patients diagnosed with solid cancer might be skewed toward class-switching to IgA, possibly reflecting Th2-polarized immunity. Impact: Further combinatorial analyses of serum immunoglobulin isotypes alongside other immune parameters in databases and observational studies are warranted.A free light chains test measures the amount of lambda and kappa free light chains in your blood. If the amount of free light chains is higher or lower than normal, it may be a sign of a disorder of the plasma cells. These disorders include multiple myeloma, a cancer that begins in the plasma cells, and amyloidosis, a condition that occurs when ...In a single day in parliament, the Modi government had three estimates for vaccine production Serum Institute of India and Bharat Biotech. The Narendra Modi government seems unsure...Abnormal serum immunoglobulin (Ig) free light chains (FLC) are established biomarkers of early disease in multiple B-cell lymphoid malignancies, including chronic lymphocytic leukemia (CLL). Heavy ... Globulin Blood Test. Healthcare providers use globulin blood tests to measure protein levels in your blood. Your liver makes globulin, a protein. High levels may indicate autoimmune disease, infections or cancer. A low globulin reading may be a sign of liver or kidney disease. A globulin test may be part of liver function tests or a metabolic ... Immunoglobulin A (IgA) is an antibody blood protein that’s part of your immune system. Your body makes IgA and other type of antibodies to help fight off sickness. Having an IgA deficiency means that you have low levels of or no IgA in your blood. IgA is found in mucous membranes, mainly in the respiratory and digestive tracts. ….

IgA nephropathy (nuh-FROP-uh-thee), also known as Berger disease, is a kidney disease. It happens when a germ-fighting protein called immunoglobulin A (IgA) builds up in the kidneys. This causes a type of swelling called inflammation that, over time, can make it harder for the kidneys to filter waste from the blood.Mar 12, 2019 · Objective. Currently, no satisfactory targets for colorectal cancer or markers for immunotherapy and diagnosis and prognosis are available. Immunoglobulin G (IgG) is widely expressed in many cancers, and it promotes cancer progression. This study explored the role of cancer-derived IgG (CIgG) in colorectal cancer. Dec 15, 2007 · Serum IgA tTG levels typically decrease as patients maintain a glutenfree diet. Celiac disease (or celiac sprue) is an autoimmune disorder with a prevalence of approximately 0.5 to 1 percent in ... Plasma cells are protein-making cells participating in humoral immune responses against bacteria, viruses, fungi, parasites, cellular antigens, chemicals, and synthetic substances. [1] Immunoglobulins constitute about 20% of the protein in plasma. The immunogen or antigen reacts with a B-cell receptor (BCR) on the cell surface of B …Clinically, serum immunoglobulin levels are frequently increased in patients with cirrhosis, and the elevation of a specific class of serum immunoglobulin is associated with a distinct liver disease. For example, elevated IgM is correlated with primary biliary cirrhosis, elevated IgG with autoimmune hepatitis, and elevated IgA in alcoholic ...Your immunoglobulin result is really just out of range. It is probably within range at my lab. Lab ranges are based on the populations they serve. So, no worries. My IgA is very elevated (around 800) and it is chronic. Enough that my doctor keeps an eye on my other immunoglobulin types for cancer.weight loss. bruises or other skin lesions. blurred vision. swelling of the lymph nodes, spleen, or liver. This test alone cannot be used to make a diagnosis. The test only indicates whether ...Objective. Currently, no satisfactory targets for colorectal cancer or markers for immunotherapy and diagnosis and prognosis are available. Immunoglobulin G (IgG) is widely expressed in many cancers, and it promotes cancer progression. This study explored the role of cancer-derived IgG (CIgG) in colorectal cancer.Immunoglobulin M (IgM), which is found mainly in the blood and lymph fluid, is the first antibody to be made by the body to fight a new infection. Expressed on the surface of B cells (monomer) and in a secreted form (pentamer) with very high avidity (forms multiple binding sites with antigen).The high prevalence of IgA in mucosal areas is a result of a cooperation between plasma cells that produce polymeric IgA (pIgA), and mucosal epithelial cells that express polymeric immunoglobulin receptor (pIgR). Polymeric IgA (mainly the secretory dimer) is produced by plasma cells in the lamina propria adjacent to mucosal surfaces. Immunoglobulin a qn serum high cancer, IgG stands for immunoglobulin G. It is a type of antibody. Antibodies are proteins that your immune system makes to fight germs. A CSF IgG index measures the levels of IgG in your cerebrospinal fluid. Normally you have a tiny amount of IgG in your cerebrospinal fluid. High levels of IgG may mean you have an infection or an inflammatory or ..., Abstract. Serum immunoglobulin levels IgA, IgG, and IgM have been estimated in 92 patients with breast cancer and 50 control patients, 40 of whom had benign disease of the breast. In patients with breast cancer, IgA was significantly raised at all stages and IgG was significantly reduced, but the two abnormalities were not necessarily concomitant., 8 IgG is the predominant immunoglobulin in normal serum (70–75%, ∼1,000 mg/dL). 9 Immunoglobulins are the carriers of humoral immunity, and hence, every increased or reduced value of certain groups of proteins is an indicator not only of the existence of some morbid process but also of the degree of its activity. 10, The serum IgG levels were high during the newborn period, decreased until the sixth month, and again increased to a maximum level at the age of 18 years. The level of IgA was found to be extremely low in the newborn period and then increased with age. While the lowest value was in the newborn period for serum IgM level, the highest value …, Immunoglobulin G (IgG), quantified in serum and expressed in quantitative terms, is a fundamental marker in immunology and a predominant antibody class in the body's immune response. Representing about 75% of serum antibodies in humans, IgG plays a critical role in identifying and neutralizing foreign pathogens like bacteria and viruses ., Abstract. Immunoglobulin A (IgA) is a major immunoglobulin isotype in the gut and plays a role in maintenance of gut homeostasis. Secretory IgA (SIgA) has multiple functions in the gut, such as to regulate microbiota composition, to protect intestinal epithelium from pathogenic microorganisms, and to help for immune-system development., Clinically, serum immunoglobulin levels are frequently increased in patients with cirrhosis, and the elevation of a specific class of serum immunoglobulin is associated with a distinct liver disease. For example, elevated IgM is correlated with primary biliary cirrhosis, elevated IgG with autoimmune hepatitis, and elevated IgA in alcoholic ..., Immunoglobulin A (IgA), one of the five primary immunoglobulins, plays a pivotal role in mucosal homeostasis in the gastrointestinal, respiratory, and genitourinary tracts, functioning as the dominant antibody of immunity in this role.. What is an immunoglobulin? Immunoglobulins, also known as antibodies, are glycoprotein molecules produced by …, The abnormal immunoglobulin made in WM is an IgM antibody. This antibody is monoclonal, meaning that it is many copies of the exact same antibody. Serum protein electrophoresis (or SPEP) is a test that measures the total amount of immunoglobulins in the blood and finds any monoclonal immunoglobulin., Immunoglobulin A (IgA) is an antibody blood protein that’s part of your immune system. Your body makes IgA and other type of antibodies to help fight off sickness. Having an …, High levels of Immunoglobulin A (IgA) in serum can indicate an underlying condition such as a monoclonal gammopathy, which is commonly associated with certain types of cancer like multiple myeloma. Multiple myeloma is a cancer of antibody-secreting cells that produces abnormal antibodies known as monoclonal proteins., Previous studies have shown that elevated serum levels of anti-H. pylori IgA is a sensitive indicator of gastric cancer risk [16, 17]. To determine the influence of humoral immune responses against H. pylori infection on gastric carcinoma, we assessed the presence of anti- H. pylori IgG and IgA levels in gastric adenocarcinoma patients and non ..., 1. Introduction. High IgM levels are found in rare immunological disorders, such as hyper IgM (HIGM) syndromes, but also in autoimmune or acquired infectious diseases [1,2,3].Elevated monoclonal IgM levels are also found in B-cell lymphoproliferative disorders (LPD) [4,5].HIGM syndromes are characterized by normal or increased IgM …, An immunofixation blood test, also known as protein electrophoresis, measures certain proteins in the blood. Proteins play many important roles, including providing energy for the body, rebuilding muscles, and supporting the immune system. There are two main types of proteins in the blood: albumin and globulin., Mar 5, 2022 · However, some people who have IgA deficiency experience pneumonia, ear infections, sinus infections, allergies, asthma and diarrhea. Autoimmune diseases, in which your immune system attacks particular organs or tissues in your own body, can be found with selective IgA deficiency. Common autoimmune conditions found with IgA deficiency include ... , A reduction of these properties can be observed when targeting cancer cells with IgH-siRNA, IgL-siRNA, or anti-human IgG antibodies. CIgG: cancer-derived IgG, …, Abstract. Immunoglobulin A (IgA) is a major immunoglobulin isotype in the gut and plays a role in maintenance of gut homeostasis. Secretory IgA (SIgA) has multiple functions in the gut, such as to regulate microbiota composition, to protect intestinal epithelium from pathogenic microorganisms, and to help for immune-system development., Traditionally, immunoglobulin (Ig) was believed to be produced by only B-lineage cells. However, increasing evidence has revealed a high level of Ig expression in cancer cells, …, One out of every seventy-three women will develop ovarian cancer in their lifetime. It has become the fifth most common cancer found in women. One out of every seventy-three women ..., Multivariate Cox regression (adjusted for age, gender, education, CCI, and serum glucose level) for the association between immunoglobulin G and the risk of pancreatic cancer showed that, compared to the IgG reference level of 6.10–14.99 g/L, there was a positive association for those with IgG levels <6.10 g/L [HR: 1.69 (95% CI …, Immunoglobulins are given through a vein or by injection to boost the immune system. Autoimmune disease treatment is based on the specific problem. Note: People with complete IgA deficiency may develop anti-IgA antibodies if given blood products and immunoglobulins. This may lead to allergies or life-threatening anaphylactic shock. However ..., Serum immunoglobulins are part of the adaptive immune system and comprise five classes, including immunoglobulin A, G, and M (IgA, IgG, and IgM). IgM provides a rapid immune response and is involved in tissue homeostasis, whereas IgG and IgA are long-lasting high-affinity antibodies, the latter mainly providing mucosal immunity …, Deamidated gliadin peptide, IgA and IgG, abbreviated DGP – IgA/ IgG has a high specificity and is considered a useful test among patients who have selective Immunoglobulin A (IgA) deficiency. EMA Celiac Disease Test. Endomysial antibody, IgA, abbreviated EMA-IgA. [Note: endomysium is a thin connective tissue layer that covers muscle fibers., Clinically, serum immunoglobulin levels are frequently increased in patients with cirrhosis, and the elevation of a specific class of serum immunoglobulin is associated with a distinct liver disease. For example, elevated IgM is correlated with primary biliary cirrhosis, elevated IgG with autoimmune hepatitis, and elevated IgA in alcoholic ..., If your immunoglobulin levels are too high, it may be a sign of an autoimmune disease, a chronic illness, an infection, or a type of cancer. Symptoms of these conditions vary …, We would like to show you a description here but the site won’t allow us., We would like to show you a description here but the site won’t allow us., Immunoglobulin A (IgA) has been shown to be an available, simple, inexpensive biomarker that could indicate liver fibrosis in these patients. Ultimately, it appears that a combination of serum biomarkers and imaging studies could replace liver biopsy in the near future., Breast cancer is common and can be devastating, but it gets a lot more media attention than many other cancers. Here are a few causes that could use a little love while you’ve got ..., A reduction of these properties can be observed when targeting cancer cells with IgH-siRNA, IgL-siRNA, or anti-human IgG antibodies. CIgG: cancer-derived IgG, …, Clinical Information. The gamma globulin band as seen in conventional serum protein electrophoresis consists of 5 immunoglobulins. In normal serum, about 15% is IgA. Monoclonal gammopathies of all types may lead to a spike in the gamma globulin zone seen on serum protein electrophoresis. Monoclonal elevations of IgA characterize multiple myeloma., While researchers have known for years that immunoglobulin A (IgA) is important for gut health, it has remained unclear exactly what role it plays in preventing infection and disease. But now ..., Polyclonal gammopathy, also called hypergammaglobulinemia, happens when your immune system makes too many immunoglobulins (antibodies). These extra antibodies show that your immune system is working too hard. Your healthcare provider treats the condition that’s causing your immune system to produce too many antibodies. Medically Reviewed.